More Spider Sox

Our BMC Evo Biol paper with the McGregor Lab is finally out !

Overlapping SoxB expression in the Spider neuroectoderm

New Hox Paper

Our work examining the selectivity of Hox transcription factor binding in a model cell line system reveals that much of the specificity is driven by chromatin accessibility and the ability of some Hox proteins to bind in closed chromatin. Great collaborative project with Rob White, with excellent experimental and analytical work from Damiano Porcelli and Bettina Fischer. Out now on bioRxiv

Spider Sox

Had great fun last summer in the McGregor Lab in Oxford-Brookes looking at spider Sox. Particular thanks to Chris and Alistair. The result was 2 BioRxiv preprints check them out here:

Paese CLB, Schoenauer A, Leite DJ,  Russell S, McGregor AP.  (2018)  A SoxB gene acts as an anterior gap gene and regulates posterior segment addition in the spider Parasteatoda tepidariorum. bioRxiv     Now published in eLIFE

Paese CLB, Leite DJ, Schoenauer A, McGregor AP, Russell S. (2017) Duplication and divergence of Sox genes in spiders. bioRxiv 

New(ish) students

Olimpia Bompadre and Maria Ouvarova join the lab for a Sox MPhil and Fat flies PhD respectively. Maria is working on a joint project with Jules Griffin and Kathryn Lilly in Biochemistry. Maria has been in the lab for a while but I’ve beed tardy in updating the website 🙁

Cambridge Beer Fest

It’s summery at the 44th Cambridge Beer Festival 🙂

New Chromatin Paper

Our new paper with Rob White’s lab on the organisation of the fly genome into H3K27me3 deleted and enriched domains  will appear in PLoS ONE shortly. Preprint is available from BioRxiv 

Alex Post viva and farewell

We bade farewell to Alex after he successfully defended his PhD thesis on Friday. Thanks for all your efforts Alex and best wishes for your future – in the meantime, enjoy Chinese New Year at home.

New Papers

Untitled 4 new papers from the lab over the past few weeks. Thanks everyone!

Niwa et al BMC Evol Biol. 16:173 shows that fly SoxN can substitute for Sox2 in vivo in mice. Fabre et al Proteomics 16:2068 is the first output from our Fly embryonic proteome project. Lee et al., in press in PLoS Genetics and available as a preprint in bioRxiv, looks at the effects of heterozygosity on the Drosophila regulatory network. El-Sharnouby et al is on bioRxiv and defines H3K27Me3 levels as a mark partitioning the genome into TADs.


The Lab – From L-R, Top row first:

Stefan, Carlo, Alex, Dagmara, Bettina, Josh, Dam, Steve.


Stefan joins the lab


We are excited to have Stefan Koestler  join the group  to work on our BBSRC funded project exploring the specificity and redundancy of fly Sox proteins.  After a PhD and Postdoc at the Institute of Molecular Biotechnology in Vienna where he did some excellent work on the cell biology of lamellipodia, Stefan spent 4 years in the Department of Molecular Biology and Genetics, Bogaziçi University Istanbul where he was working on Fly photoreceptor differentiation. Stefan has expertise in molecular biology and considerable experience with static and real time imaging at the cellular level. Here are a couple of his papers you can enjoy.

Koestler et al (2015).  FlyOde – A platform for community curation and interactive visualization of dynamic gene regulatory networks in Drosophila eye development.
F1000Research, 4:1484; WWW resource: 

Koestler et al 2013. Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin.  Mol Biol Cell. 24(18):2861-75.


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