We bade farewell to Alex after he successfully defended his PhD thesis on Friday. Thanks for all your efforts Alex and best wishes for your future – in the meantime, enjoy Chinese New Year at home.
Niwa et al BMC Evol Biol. 16:173 shows that fly SoxN can substitute for Sox2 in vivo in mice. Fabre et al Proteomics 16:2068 is the first output from our Fly embryonic proteome project. Lee et al., in press in PLoS Genetics and available as a preprint in bioRxiv, looks at the effects of heterozygosity on the Drosophila regulatory network. El-Sharnouby et al is on bioRxiv and defines H3K27Me3 levels as a mark partitioning the genome into TADs.
We are excited to have Stefan Koestler join the group to work on our BBSRC funded project exploring the specificity and redundancy of fly Sox proteins. After a PhD and Postdoc at the Institute of Molecular Biotechnology in Vienna where he did some excellent work on the cell biology of lamellipodia, Stefan spent 4 years in the Department of Molecular Biology and Genetics, Bogaziçi University Istanbul where he was working on Fly photoreceptor differentiation. Stefan has expertise in molecular biology and considerable experience with static and real time imaging at the cellular level. Here are a couple of his papers you can enjoy.
Koestler et al (2015). FlyOde – A platform for community curation and interactive visualization of dynamic gene regulatory networks in Drosophila eye development.
Koestler et al 2013. Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin. Mol Biol Cell. 24(18):2861-75.
The considerable debate/discussion on my twitter feed regarding HIF journals prompts me to post the 1st edition of Cool. This appeared on the Glasgow Genetics Department Fax machine in the summer of 1990, shortly before I left for Cambridge. It has been on my office wall ever since and acts as a timely reminder that it is not where you publish but what you publish that should matter. The full version in all its glory is here – Cool-Article
The advent of CRISPR-Cas9 based genome engineering has opened up many avenues for genome engineering in many organisms. A group of Drosophila researchers active in the field have published some guidance and recommendations for using gene drive systems based on our collective experiences. We highlight some of the potential problems, provide suggestions for using drive-based systems and call for transparency in the use of these systems in the laboratory. The consensus view of our group is available now in Science.
Hot on the heels of Dichaete’s 100th birthday, today sees the 25th birthday of the publications describing the identification of SRY, the founder of the Sox family. Work from the labs of Peter Goodfellow and Robin Lovell-Badge (working in human and mouse respectively) demonstrated that the gene on the Y-chromosome controlling mammalian sex-determination encoded a new class of transcription factors and Sox was born.