Cambridge Beer Fest

It’s summery at the 44th Cambridge Beer Festival ūüôā

New Chromatin Paper

Our new paper with Rob White’s lab on the organisation of the fly genome into H3K27me3 deleted and enriched domains ¬†will appear in PLoS ONE shortly. Preprint is available from BioRxiv¬†

Alex Post viva and farewell

We bade farewell to Alex after he successfully defended his PhD thesis on Friday. Thanks for all your efforts Alex and best wishes for your future – in the meantime, enjoy Chinese New Year at home.

New Papers

Untitled 4 new papers from the lab over the past few weeks. Thanks everyone!

Niwa et al BMC Evol Biol. 16:173 shows that fly SoxN can substitute for Sox2 in vivo in mice. Fabre et al Proteomics 16:2068 is the first output from our Fly embryonic proteome project. Lee et al., in press in PLoS Genetics and available as a preprint in bioRxiv, looks at the effects of heterozygosity on the Drosophila regulatory network. El-Sharnouby et al is on bioRxiv and defines H3K27Me3 levels as a mark partitioning the genome into TADs.

ScienceIsGlobal

The Lab¬†–¬†From L-R, Top row first:

Stefan, Carlo, Alex, Dagmara, Bettina, Josh, Dam, Steve.

DSC_0400

Stefan joins the lab

IMG_0455

We are excited to have Stefan Koestler  join the group  to work on our BBSRC funded project exploring the specificity and redundancy of fly Sox proteins.  After a PhD and Postdoc at the Institute of Molecular Biotechnology in Vienna where he did some excellent work on the cell biology of lamellipodia, Stefan spent 4 years in the Department of Molecular Biology and Genetics, Bogaziçi University Istanbul where he was working on Fly photoreceptor differentiation. Stefan has expertise in molecular biology and considerable experience with static and real time imaging at the cellular level. Here are a couple of his papers you can enjoy.

Koestler et al (2015).  FlyOde РA platform for community curation and interactive visualization of dynamic gene regulatory networks in Drosophila eye development.
F1000Research, 4:1484; WWW resource: http://flyode.boun.edu.tr/ 

Koestler et al 2013. Arp2/3 complex is essential for actin network treadmilling as well as for targeting of capping protein and cofilin.  Mol Biol Cell. 24(18):2861-75.

1st proteome paper out

Proteome

The first paper from our BBSRC developmental proteome project is now out Рa pilot study investigating the optimal approaches for label-free quantitation (Proteomics 2015)[PubMed]

New Hox Paper

Hox_bindOur paper with Rob White’s group on Hox specificity and Chromatin is now available in Epigentics & Chromatin.

Anopheles Gene Drive

Our Target Malaria consortium paper demonstrating how CRISPR-CAS9 can be used to drive disruption of female fertility genes is out now in Nature Biotechnology. A great job led by Tony Nolan in the Imperial College team.Drive

Cool

CoolThe considerable debate/discussion on my twitter feed regarding HIF journals prompts me to post the 1st edition of Cool. This appeared on¬†the Glasgow Genetics Department Fax machine in the summer of 1990, shortly before I left for Cambridge. It has been on my office wall ever since and¬†acts as a timely reminder that it is not where you publish but what you publish that should matter. The full version in all its glory is here –¬†Cool-Article