Sarah Submits Thesis

  Very well done to Sarah, submitting her thesis on a lovely Cambridge morning :-)


Protein Trap Paper

After almost 6 years, many millions of screened embryos and thousands of images provided by a host of labs, out Protein Trap paper finally sees the light of day in Development. A tremendous effort by all those involved. You can read it in all its (open access) glory here. There is also a fabulous accompanying paper from Bénédicte Sanson’s lab describing in detail the embryonic expression and localisation of the lines.

Thanks to all those involved.

Katerina’s thesis

Well done Katerina, thesis bound and submitted before the deadline. I am sure she now needs a considerable period of sleep!


Enrico’s paper now out

Enrico’s paper on SoxN genomics and a comparative analysis of SoxN and Dichaete binding in mutant backgrounds is now out in Genome Biology. We are very proud of this paper.

Enrico’s viva success

Congratulations to Enrico on successfully defending his PhD thesis today.  A fabulous piece of work on SoxN genome biology as well as a fascinating analysis of SoxN and Dichaete redundancy at a genomic level.

Bettina’s Bioconductor Package

A landmark for the lab with our first ever BioConductor package now available.  SimBindProfiles allows comparisons of ChIP-array binding profiles to identify differential binding in different datasets, while there are tools to this with ChIP-seq data there was little or nothing usable for array based analysis.  Bettina put it together with some help from Enrico and Robert Stojnic to facilitate our work on Dichaete and SoxN binding but it is broadly applicable to any ChIP-array datasets.

I think this is a fabulous piece of work – well done Bettina!

Dichaete Paper Out

Jelena’s Dichaete genomics paper is now out in BMC Genomics.  Great job troops.

The new grad students

A very warm welcome to Alex Chen and Josh Maher, who have just joined the lab as grad students.  Alex will be working on the Hox specificity project and Alex will be extending the Joy of Sox into other insect species.

Hope you have fun guys!


Alfonso Martinez-Arias has disseminated a copy of the spoof journal Cool (get it here) that has been pinned to my office wall for well over 20 years. I keep it to remind me what science is actually about (and Cool is not!). Alfonso uses it to illustrate some of the things enraging him about the current state of research – his blog is worth a read.

Engineering HEGs paper out

David and Sang’s work with our Colleagues at Fred Hutchinson & Pregenen in Seattle, engineering homing endonucleases to recognise new target sequences, is now available from PLoS ONE. Great job everyone.